Effect of Meperidine or Drotaverine on Effacement and Dilatation of the Cervix During Labor in Full Term Primigravidae
Conditions
Brief summary
Comparison Between Meperidine and Drotaverine Regarding the Effect on the Duration of the First Stage of Labor in Full Term Primigravidae
Detailed description
Comparison Between Meperidine and Drotaverine Regarding the Effect on the Duration of the First Stage of Labor in Full Term Primigravidae Protocol of Thesis Submitted for partial fulfillment of master degree in Obstetrics & Gynecology The aim of this work is to compare and to evaluate the efficacy of drotaverine hydrochloride versus meperidine hydrochloride on the duration of the 1st stage of labor.
Interventions
DRUGMeperidine
administer 100mg meperidine i.v during the 1st stage of labor and calculate the duration of this stage of labor
DRUGDrotaverine
administer 40mg drotaverine i.v during the 1st stage of labor and calculate the duration of this stage of labor
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Healthy volunteers
Yes
Inclusion criteria
● primigravida. * Singleton pregnancy. * Term gestation i.e, 38-41 weeks. * Sure, reliable dates documented by ultrasound in the 1st half of pregnancy. * Vertex presentation with occipito anterior position. * Efficient uterine contractions at a rate of at least 3 to 4 contractions every 10 minutes, each contraction lasting for at least 40 seconds.
Exclusion criteria
● Abnormal presentation or occipito posterior position. * Multiple pregnancies. * Cephalo-pelvic disproportion. * Cervical surgery in the past or history of cervical injury. * Patients on antihypertensive therapy. * Known hypersensitivity to drotaverine or meperidine. * If any other spasmolytic agent had been used within 48 hours.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the duration of the first stage of labor | 6 monthes | the primary outcome is to evaluate whether meperidine or drotaverine is more effective in shortening the duration of the 1st stage of labor |
| effect on the duration of the 1st stage of labor | 6 monthes | the primary outcome is to evaluate whether meperidine or drotaverine is more effective on the duration of the 1st stage of labor |
Secondary
| Measure | Time frame |
|---|---|
| effect on pain | 6 monthes |
Countries
Egypt
Contacts
Primary Contactmahmoud mohamed
Backup ContactM H
Outcome results
None listed