Comparison for Pethidine Requirement in Patients Received Spinal Morphine 0.2 and 0.3 mg for Post Lobectomy Analgesia

Comparison for Pethidine Requirement in Patients Received Spinal Morphine 0.2 and 0.3 Milligram for Post Lobectomy (Lung) Analgesia

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01236495

Acronym

pain

Enrollment

Registered

2010-11-08

Start date

2010-11-30

Completion date

2012-03-31

Last updated

2012-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Diseases, Solitary Mass

Keywords

thoracotomy, postoperative pain, spinal morphine

Brief summary

The purpose of the study is to evaluate the amount of total pethidine requirement during the 48 hour postoperative period after receiving spinal morphine 0.2 and 0.3 mg.

Detailed description

Thoracotomy causes severe pain to the patients. Continuous thoracic epidural is a gold standard for postoperative pain. However, it needs skill. There are many alternatives such as spinal morphine, intercostal nerve block, cryoalangesia or interpleural block.

Interventions

DRUGspinal morphine 0.3 mg

spinal morphine 0.3 mg

DRUGspinal morphine 0.2 mg

spinal morphine 0.2 mg

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Age \> 18 year and \< 70 year * Patient ASA physical status I-III. * Scheduled for thoracotomy with lobectomy. * Can operate a patient-controlled analgesia (PCA) device.

Exclusion criteria

* Known hypersensitivity to morphine or pethidine * History of bleeding tendency. * Known case of infection at the back * Patient refuse for spinal anesthesia * History of cerebrovascular disease. * Scheduled for video-assisted thoracoscopic lobectomy. * Need mechanical ventilatory support during postoperative period

Design outcomes

Primary

Measure	Time frame	Description
pethidine requirement	48 hours	Total pethidine requirement during 48 hours postoperative

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026