Eosinophilic Esophagitis
Conditions
Brief summary
Confocal laser endomicroscopy enables in vivo microscopic imaging within the mucosa layer of the gut at a subcellular resolution. Various studies have addressed the potential of endomicroscopy for the in vivo diagnosis of esophageal squamous cell carcinoma, Barrett´s esophagus and esophageal adenocarcinoma. Currently, there is only one case report from our group who noted the utility of endomicroscopy for the in vivo diagnosis of eosinophilic esophagitis. The purpose of this study is to determine whether endomicroscopy is effective for the in vivo diagnosis of eosinophilic esophagitis.
Interventions
DEVICEConfocal laser endomicroscopy
Confocal laser endomicroscopy
Sponsors
University of Erlangen-Nürnberg Medical School
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Written informed consent * Age 18-85 years * Ability of subjects to understand character and individual consequences of clinical trial * Subjects undergoing EGD
Exclusion criteria
* Inability to provide written informed consent * Severe Coagulopathy (Prothrombin time \< 50% of control, Partial thromboplastin time \> 50 s) * Impaired renal function (Creatinine \> 1.2 mg/dl) * Pregnancy or breast feeding * Active gastrointestinal bleeding * Known allergy to fluorescein, acriflavin or cresyl violet * Residing in institutions (e.g. prison)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effectiveness of endomicroscopy for the in vivo diagnosis of eosinophilic esophagitis | November 2010 - November 2012 |
Secondary
| Measure | Time frame |
|---|---|
| Differentiation of mucosal alterations in patients with eosinophilic esophagitis compared to patients with gastroesophageal reflux disease. | November 2010 - November 2012 |
Countries
Germany
Outcome results
None listed