Renal Transplant
Conditions
Keywords
Renal allograft, kidney, fibrosis, elastography, elasticity
Brief summary
The purpose of this study is to assess the potential of elastography for noninvasive assessment of fibrosis in renal allograft.
Interventions
DEVICEMagnetic Resonance Elastography, and Supersonic Shear Imaging
Magnetic Resonance Elastography, and Supersonic Shear Imaging
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Renal allograft performed less than 3 months before enrolment
Exclusion criteria
* Contra-indication to magnetic resonance imaging * Contra-indication to biopsy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation between elasticity (as measured by elastography) and (a) Banff score for fibrosis, (b) glomerular filtration rate assessed by creatinine clearance, (c) glomerular filtration rate assessed by insulin clearance | 3 months and 12 months after graft |
Secondary
| Measure | Time frame |
|---|---|
| Number of technical failures | 12 months |
| Tolerance (assessed by a questionnaire) | 3 months and 12 months after graft |
| Evolution of the elasticity of the transplant between 3 and 12 months after graft | 3 months and 12 months after graft |
| Correlation between elasticity and arterial resistance index | 3 months and 12 months after graft |
Countries
France
Contacts
Primary ContactROUVIERE Olivier, Pr
Outcome results
None listed