Atrial Fibrillation
Conditions
Brief summary
In the present application, we propose to refine and extend current insight into AAF mechanism and therapy by examining the importance of pharmacologic RAAS inhibition, ACE genotype, and their interaction in secondary AF prevention. We have 3 specific aims: 1. To confirm that RAAS inhibition therapy reduces the incidence of AF recurrence. 2. To test the hypothesis that the incidence of AF recurrence in the absence of RAAS inhibition therapy is higher among patients with the D allele. 3. To explore the hypothesis that RAAS inhibition therapy is more effective for preventing AF recurrence in patients with the DD genotype than in those with DI or II genotypes.
Interventions
OTHERno drug
none, no drug
DRUGstart cozaar
start cozaar
DRUGcontinue cozaar
continue cozaar
Sponsors
University of Pittsburgh
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Subjects must be in atrial fibrillation confirmed by 12 lead EKG. * blood pressure \> 90 mmHg * Patient without cardiopulmonary symptoms * 18+ years of age
Exclusion criteria
* Contraindiction to warfarin * Recent (within 6 months) MI or cardiac revascularization * Recent (within 6 months) CVA or TIA * NYHA Class IV CHF * Active thyroid disease * Major hepatic dysfunction * Renal dysfunction (\>2 mg/dL) * Hyperkalemia (\>4.6 mEq/L) * Hyponatremia (\<130 mEq/L) * Currently taking a Vaughn-Williams Type I or III antiarrhythmic drug * History of ARB intolerance * Contraindication to ARB therapy * Pregnancy * Female of childbearing age * Age \< 18 years of age * Inability to give informed consent * Other medical conditions calling 1 year survival into question
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AF burden | 1 year |
Countries
United States
Outcome results
None listed