Leukemia
Conditions
Keywords
adult acute myeloid leukemia, childhood acute myeloid leukemia/other myeloid malignancies
Brief summary
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. PURPOSE: This research study is studying biomarkers in tissue samples from patients with acute myeloid leukemia.
Detailed description
OBJECTIVES: * Determine the frequency of acute myeloid leukemia (AML) that originates in CD33+ precursors or in which uncontrolled growth is restricted to CD33+ precursors. OUTLINE: Cryopreserved acute myeloid leukemia cell samples are separated from endothelial cell by fluorescent-activated cell sorting (FACS) and analyzed for X-chromosome inactivation patterns by cytogenetic/molecular analysis and/or Humara assay.
Interventions
GENETICcytogenetic analysis
OTHERHUMARA assay
OTHERlaboratory biomarker analysis
Sponsors
National Cancer Institute (NCI)
Children's Oncology Group
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
No minimum to 120 Years
Healthy volunteers
No
Inclusion criteria
DISEASE CHARACTERISTICS: * Diagnosed with acute myeloid leukemia * Known CD34+ progenitor cells * Available freshly isolated, uncultured cell samples PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency of AML that originate in CD33+ or in which uncontrolled growth is restricted to CD33+ precursors | — |
| Extent of clonal hematopoiesis in small numbers of AML cells | — |
Outcome results
None listed