Incretin Action, Obesity
Conditions
Keywords
Incretin hormones, Glucagon, Satiety, Hunger, Energy expenditure
Brief summary
Tiny molecules (hormones) are released from the bowels and other organs to the bloodstream in response to meals in order to orchestrate the metabolism. Oxyntomodulin, GLP-1 and glucagon are all known to regulate parameters such as appetite, food intake and induce weight loss. Therefore we want to investigate mechanistic relations between the three hormones.
Interventions
OTHERGLP-1 infusion
1 pmol/kg/min
OTHERGlucagon infusion
3ng/kg/min
OTHEROxyntomodulin infusion
3 pmol/kg/min
OTHERGLP-1 and glucagon infusion
1 pmol/kg/min 3 ng/kg/min
OTHERPlacebo
NaCl 9 g/L infusion
Sponsors
University Hospital, Gentofte, Copenhagen
Eligibility
Sex/Gender
MALE
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Normal fasting plasma glucose * Normal glucose tolerance * Normal haemoglobin levels * Informed content
Exclusion criteria
* Diabetes * Pre diabetes (impaired glucose tolerance or impaired fasting glucose) * 1st degree relatives with diabetes * Obesity (BMI \> 30) * Inflammatory bowels disease * Bowels surgery * Nephropathy * Liver disease * Medication which cannot be on hold for 24h
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| basal energy expenditure | 2 x 30min | Assessed by indirect calorimetry |
| Gastric emptying | 4 h | Assessed by the acetaminophen - method |
| Satiety | 4 h | Assessed by VAS |
| Hunger | 4 h | Assessed by an ad'libitum meal |
Secondary
| Measure | Time frame |
|---|---|
| GLP-1 | 4 h |
| Oxyntomodulin | 4 h |
| Glucagon | 4 h |
| GIP | 4 h |
Countries
Denmark
Outcome results
None listed