Methicillin-resistant Staphylococcus Aureus
Conditions
Keywords
methicillin-resistant Staphylococcus aureus, decolonization, random allocation, outpatient
Brief summary
The purpose of this study is to determine the effectiveness of topical and oral antibiotics in eliminating carriage of methicillin-resistant Staphylococcus aureus (MRSA) among those living in the community. We hypothesize that a greater proportion of those who receive intervention will eliminate MRSA carriage compared to those who do not receive any intervention.
Interventions
DRUGpharmacological decolonization treatment
Chlorhexidine gluconate 4% body scrub and 2% shampoo daily PLUS mupirocin 2%, fusidic acid 2%, or chlorhexidine gluconate 0.2% intranasally bid PLUS trimethoprim-sulfamethoxazole 160/800mg po bid or doxycycline 100mg po bid all for 7 days
BEHAVIORALEducation
No pharmacological decolonization treatment but given education regarding personal hygiene and environmental cleaning
Sponsors
Alberta Health services
Joseph Kim
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Prior MRSA infection (i.e index case) * Identified as being colonized with MRSA on initial screen
Exclusion criteria
* Are pregnant or breastfeeding. * Have indwelling catheters. * Received prior decolonization treatment within last 6 months of enrollment. * Have allergy to study medication. * Are colonized with MRSA strain resistant to study medication. * Have active infection requiring systemic antimicrobials. * Are household contacts to index case.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication of MRSA carriage | 90 days after randomization |
Secondary
| Measure | Time frame |
|---|---|
| Occurrence of MRSA infection | Within 6 months of randomization |
Countries
Canada
Outcome results
None listed