Aging
Conditions
Keywords
Aging lung, Airway remodeling, Airway segmentation, Chest CT
Brief summary
The aim of the study is to investigate the relationship between aging and morphological changes in the lung. 120 consecutive healthy volunteers over 60 years will be enrolled for this trial.
Detailed description
Chest multidetector CT without injection and spirometry data will be obtained from a multicentric sample of individuals between 60 and 95 years of ageExclusion criteria were current smoking, history of smoking within the past 10 years, any known chronic or acute pulmonary disease. Individuals treated with Amiodarone, Bleomycin or methotrexate were excludedOutcome
Interventions
OTHEREFR and TDM
EFR : Pulmonary function test TDM : tomodensitometry
Sponsors
University Hospital, Montpellier
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
60 Years to 95 Years
Healthy volunteers
Yes
Inclusion criteria
* People from 60 to 95 years old free from chest disease or history of chest disease
Exclusion criteria
* Chronic cough * Dyspnea * Sinonasal or chest infection during enrollment * Myocardial infarction. * Current smoker or past smoker with more than 10 pack year intoxication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bronchial wall thickness | 1 day | Bronchial wall thickness and remodeling associated with aging |
Countries
France
Outcome results
None listed