Stepwise Approach Versus Linear Ablation in Patients With Recurrence of Persistent Atrial Fibrillation

Stepwise Approach Versus Linear Ablation for Repeat Procedure in Patients With Recurrence of Persistent Atrial Fibrillation

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01229475

Acronym

REDO-AF

Enrollment

130

Registered

2010-10-27

Start date

2010-10-31

Completion date

2013-12-31

Last updated

2013-03-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Atrial Fibrillation, Recurrence

Keywords

Atrial fibrillation, recurrence, repeat procedure, linear ablation, stepwise approach

Brief summary

Catheter ablation of persistent atrial fibrillation (AF) remains a challenging procedure. Even in experienced centres, repeat interventions are necessary in up to 70 of patients to achieve sinus rhythm at a long-term follow-up. While there is a consensus to perform pulmonary vein isolation (PVI) as a cornerstone for the ablation of paroxysmal and persistent AF ablation, different additional ablation strategies are used to achieve a modification of the substrate that perpetuates the arrhythmia: linear lesions (anterior and roof lines) or ablation of complex fractionated atrial electrograms (CFAE). In the stepwise approach PVI, CFAE ablation and/or LL are combined according to the presenting arrhythmia during procedure. The aim of the study is to determine whether there is a difference in terms of freedom from arrhythmia between a stepwise approach and a linear ablation for repeat procedure in patient with recurrence of persistent atrial fibrillation.

Interventions

PROCEDUREAblation with stepwise approach

Stepwise approach for repeat AF ablation

PROCEDURELinear ablation

Linear ablation for AF ablation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Patients with recurrence of symptomatic persistent atrial fibrillation after at least one ablation procedure, * with the last ablation procedure at least 3 months ago. * at least one unsuccessful attempt of antiarrhythmic drug * oral anticoagulation for at least 4 weeks prior to ablation

Exclusion criteria

* LA thrombus

Design outcomes

Primary

Measure	Time frame	Description
Freedom from atrial arrhythmia	—	Documented freedom from atrial arrhythmia (AF or AT) during follow-up.

Secondary

Measure	Time frame	Description
Procedural and safety data	—	1. Duration of left atrial procedure, ablation time, fluoroscopy time. 2. Complications 3. Type of recurrent arrhythmia 4. Number of reablation

Countries

Germany

Contacts

Primary ContactSonia Ammar, MD

ammar@dhm.mhn.de+49891218

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026