Leukemia
Conditions
Keywords
childhood acute myeloid leukemia/other myeloid malignancies
Brief summary
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in RNA and identify biomarkers related to cancer. PURPOSE: This research study is studying RNA biomarkers in tissue samples from infants with acute myeloid leukemia.
Detailed description
OBJECTIVES: * Sequence the microRNAs present in 20 infant AML samples as a pilot study. * Compare microRNAs present in infant AML samples to infant ALL samples that are being concurrently sequenced in a separate study to identify lineage- and translocation-specific microRNAs. OUTLINE: This is a multicenter study. Previously collected cryopreserved cells from diagnosis are sequenced using reverse transcriptase-PCR.
Interventions
GENETICRNA analysis
GENETICnucleic acid sequencing
GENETICreverse transcriptase-polymerase chain reaction
OTHERlaboratory biomarker analysis
Sponsors
National Cancer Institute (NCI)
Children's Oncology Group
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 1 Years
Healthy volunteers
No
Inclusion criteria
DISEASE CHARACTERISTICS: * Diagnosis of acute myeloid leukemia * Available cryopreserved cells from diagnosis PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sequence of the microRNAs present in 20 infant acute myeloid leukemia (AML) samples | — |
| Comparison of microRNAs present in infant AML samples to infant acute lymphoblastic leukemia samples to identify lineage- and translocation-specific microRNAs | — |
Outcome results
None listed