Osteopenia, Osteoporosis, Sarcopenia
Conditions
Brief summary
Performing adduction and abduction resistance exercise will increase hip bone density and strength to a greater extent than doing squat and deadlift exercise. Aim #1: To determine if doing hip adduction and abduction resistance exercise training for 16 weeks improves spine bone mineral density and hip bone mineral density and strength as determined by finite element modeling. Aim #2: To compare the effects of hip adduction and abduction exercise to squat and deadlift exercise with respect to potential changes in hip bone mineral density and strength. Aim #3: To determine if the addition of adduction and abduction exercise to squat and deadlift exercise promotes an additive effect with respect to changes in spine bone mineral density and hip bone mineral density and bone strength.
Detailed description
The investigators will carry out a 16-week exercise training study (n=24) consisting of 3 groups (n=8 per group) of healthy, non-resistance trained adult men and women (age 25-55 years). Our aim is to determine if hip adduction and abduction resistance exercise is more effective than squat and deadlift exercise with respect to changes in the whole bone strength and density of the proximal femur and spine. Group A will do only hip adduction and abduction exercises. Group B will do only squat and deadlift exercise Group C will do a combination of hip adduction and abduction and squat and deadlift exercise Subjects will be imaged with quantitative computed tomography (QCT) of the proximal femur and spine, pre-training and post-training, to determine changes in spinal bone density and proximal femoral bone density and strength. Serum assays of bone formation (osteocalcin) and bone resorption (serum CTX type I) will be performed four times during the study at 4 week intervals.
Interventions
OTHERexercise
Adduction, Abduction and Squat exercise three times a week for 16 weeks
Sponsors
National Space Biomedical Research Institute
University of California, San Francisco
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
25 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy men and women * Age of 25 to 55 years old
Exclusion criteria
* Hypertension (High blood pressure) * Diabetes or metabolic syndrome * Hyperlipidemia (High cholesterol) * Cardiovascular Disease * Asthma or other pulmonary disease (i.e. COPD) * not pregnant * have no joint or mobility limitations * do not exercise on a regular basis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Reduce risk of hip fracture | 16 weeks | The investigators have prioritized the last year of NSBRI funding to test one the capabilities of our device, standing hip adduction/abduction exercise, to strengthen the proximal femoral bone. We believe that if we are able to detect increases in bone density and strength (assessed using quantitative computed tomography of the hip pre- and post-training) in healthy volunteers, this will be solid preliminary evidence to support modification of exercise protocols currently being used to reduce the rate of bone loss on the International Space Station. |
Countries
United States
Outcome results
None listed