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Breaking the Cycle IV: Military PTSD (MPTSD) Treatment Study

Breaking the Cycle IV: Military PTSD (MPTSD) Treatment Study

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01228539
Acronym
MPTSD
Enrollment
31
Registered
2010-10-26
Start date
2010-01-31
Completion date
2012-12-31
Last updated
2013-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aggression, Anger, PTSD

Keywords

PTSD, Anger, Aggression, Military

Brief summary

The study will compare the efficacy of Trauma Affect Regulation: Guide for Education and Therapy (TARGET) vs. the best validated psychotherapy for adults with posttraumatic stress disorder (PTSD), Prolonged Exposure (PE). Male military personnel and veterans suffering with PTSD and problems with anger after returning from military service in Afghanistan (Operation Emerging Freedom, OEF) and/or Iraq (Operation Iraqi Freedom, OIF) will be participants. The goal is to determine if a present-centered psychotherapy that teaches skills for emotion regulation and does not require re-telling of traumatic memories is as efficacious as the trauma memory-focused PE psychotherapy.

Detailed description

The study is based on a theoretical and clinical model that involves a series of associated risks that are set in motion by exposure to military-related traumatic stressors in Iraq or Afghanistan. Trauma exposure places personnel at risk for PTSD, which in turn increases their risk of problems with anger and hostility, emotion dysregulation and experiential avoidance, and ultimately with alcohol abuse and aggression. The two types of treatments being compared, TARGET (Trauma Affect Regulation: Guide for Education and Therapy) and PE (Prolonged Exposure), are both designed to directly reduce PTSD severity by reducing emotion dysregulation (TARGET) and experiential avoidance (PE), and therefore are hypothesized to reduce the risk and severity of alcohol abuse and aggression- and thereby to reduce associated legal and societal costs.

Interventions

BEHAVIORALTARGET (Trauma Affect Regulation)

TARGET teaches a skill sequence for affect regulation and social/interpersonal information processing.

BEHAVIORALProlonged Exposure

Cognitive behavior therapy with trauma memory exposure

Sponsors

University of Pennsylvania
CollaboratorOTHER
UConn Health
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender
MALE
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* be a returning OEF/OIF military personnel or veteran * have experienced PTSD for the past month * have experienced anger and at least one act of aggression in the last month * be mentally able to provide a valid consent

Exclusion criteria

* currently be danger of suicide * currently abusing alcohol or other substances * been in an inpatient psychiatric or addiction treatment program in the past month

Design outcomes

Primary

MeasureTime frameDescription
Severity of PTSD symptomsPost-therapyClinician Administered PTSD Scale Ordinal Scores Posttraumatic Cognitions Inventory Trauma Memory Questionnaire Interpretation of PTSD Symptoms Scale

Secondary

MeasureTime frameDescription
Anger/aggression problemsPost-therapyState-Trait Anger Expression Inventory Brief Symptom Inventory
Emotion RegulationPost-therapyNegative Mood Regulation scale Difficulty with Emotion Regulation Scale Acceptance and Action Questionnaire

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 24, 2026