Depression, Depressive Symptoms
Conditions
Keywords
Pharmacogenomics, Depressed Patients
Brief summary
The purpose of this study is to determine whether genetic information associated with individual depressive symptoms.
Detailed description
The primary hypothesis is that the variations of the candidate genes are associated with individual symptoms in patients with depression. The Second hypothesis is that patients with the associated genetic variation suffer longer from the associated symptom than the patients without the associated genetic variation.
Interventions
Antidepressant administration of SSRI class for 12 weeks under therapeutic dose
Antidepressant administration of non-SSRI class for 12 weeks under therapeutic dose
Sponsors
Samsung Medical Center
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to 89 Years
Healthy volunteers
Yes
Inclusion criteria
* Eligible patients were enrolled in the clinical trials program of hte Samsung Medical Center Geropsychiatry and Affective Disorder Clinics(Seoul, Korea). They received a semistructured diagnostic interview, the Samsung Psychiatric Evaluation Schedule. The affective disorder section of the Samsung Psychiatric Evaluation Schedule uses the Korean version of the structured clinical interview for the diagnostic and statistical manual of mental disorders, Fourth edition. * interview with one more patient's family member for objective diagnosis and final diagnosis decision by agreements of two more psychiatric physicians
Exclusion criteria
* received psychotropic medication within 2 weeks of the study or fluoxetine within 4 weeks * potential study participants for pregnancy, significant medical conditions, abnormal laboratory baseline values, unstable psychiatric features(eg.suicidal), history of alcohol of drug dependence, seizures, head trauma with loss of consciousness, neurological illness, or concomitant Axis I psychiatric disorder.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Presences of each individual symptom of depression at 1,2,4,6,12 weeks | 12 weeks | 17-items HAM-D scale was employed to measure depressive symptoms |
Countries
South Korea
Contacts
Primary ContactJungShil Back, B/Sc.
Backup ContactShinn-Won Lim, phD
Outcome results
None listed