Influence of Muscle Relaxation With Rocuronium Bromide During General Anaesthesia on Muscle Trauma and Postoperative Analgetic Consumption in Patients With Total Hip Prosthesis Implantation

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01228162

Enrollment

120

Registered

2010-10-26

Start date

2010-09-30

Completion date

2013-06-30

Last updated

2013-06-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Analgetic Consumption, Muscle Relaxation, Muscle Trauma, Total Hip Replacement

Brief summary

The researchers want to investigate the effects of muscle relaxation with rocuronium bromide during general anaesthesia on muscle trauma (serum CK, CRP) and postoperative analgesic consumption in patients with total hip prosthesis replacement (general vs. spinal anaesthesia).

Interventions

PROCEDUREeffect of muscle relaxation on muscle trauma, control group without relaxation

effect of muscle relaxation on muscle trauma, control group without relaxation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

55 Years to 80 Years

Healthy volunteers

Inclusion criteria

1. patient agreement 2. indication for total hip replacement 3. age 55 - 80 years 4. weight 65 - 95 kg 5. first intervention 6. ASA classification I - III 7. general and spinal anaesthesia possible in this patient

Exclusion criteria

a) neuromuscular diseases b) surgery with muscle trauma (within the last 3 months) c) permanent immobility d) intramuscular injections (within the last 4 weeks) e) medication with opioids f) medication with co-analgetics g) contraindications for general or spinal anaesthesia h) dementia, cognitive dysfunction or sleep apnea \-

Design outcomes

Primary

Measure	Time frame	Description
degree of muscle trauma	24 hours	serum CK and CRP levels are measured

Secondary

Measure	Time frame	Description
consumption of analgetics	3 days	consumption of piritramide is measured

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026