Acute Renal Failure
Conditions
Brief summary
The mortality of acute renal failure (ARF) remains to be high (around 60-70%) despite manifold improvements in ICU care. At present, it is not clear if the method chosen for renal replacement therapy, i.e. intermittent haemodialysis (IHD) or continuous haemofiltration (CVVH), might impact on the outcome of these patients. For this purpose, a prospective randomised clinical study of the effect of continuous versus intermittent renal replacement therapy on the mortality and outcome of acute renal failure will be performed.
Detailed description
please see above
Interventions
OTHERRRT for acute kidney failure using the CVVH method
patients randomized to receive CVVH
OTHERRRT for acute kidney failure using the IHD (intermittent HD)
patients randomized to receive IHD
Sponsors
Charite University, Berlin, Germany
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* all ICU patients requiring renal replacement therapy
Exclusion criteria
* patient denies informed consent * patient not requiring intensive care therapy * kidney transplanted patients * chronic renal failure (serum creatinine \> 3mg/dl)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival at 2 weeks after RRT | 2 weeks after RRT in follow-up |
Countries
Germany
Outcome results
None listed