Asian Patients With Advanced Gastro-intestinal Stromal Tumors (GIST) Treated With Imatinib
Conditions
Keywords
Advanced gastro-intestinal stromal tumors
Brief summary
Imatinib is the current standard treatment for advanced GIST. Previous studies have shown that GIST genotype was associated with treatment outcomes with exon 11 having superior outcome compared with exon 9 or WT.10, 11 In patients with exon 9 kit mutation, the response rate was higher at when imatinib was given at 800mg daily compared with the standard dose of 400mg daily. Although the data linking tyrosine kinase mutation status and imatinib response in metastatic GISTs is intriguing, more information is needed before mutation testing is adopted as part of the routine analysis of high-risk or overtly malignant KIT-expressing GISTs.25 Despite the fact that exon 9 mutations are associated with a lower response rate, overall survival does not appear to be better with high-dose therapy. The investigators propose to conduct a retrospective analysis of mutational analysis on patients with GIST and determine the relationship between patient response and imatinib dose.
Interventions
PROCEDURETumor biopsies
Sponsors
National University Hospital, Singapore
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
21 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Histologic diagnosis of advanced stage or metastatic GIST 2. Asian patient (as defined by the investigator) 3. First line treatment with imatinib 4. Availability of tumor samples for kit mutation analysis 5. Availability of tumor response rate and or time to progression data
Exclusion criteria
\-
Countries
Singapore
Contacts
Primary ContactRoss Andrew Soo, MBBS
Outcome results
None listed