Diabetic Retinopathy
Conditions
Keywords
Latanoprost, vasodilation, diabetic retinopathy
Brief summary
Randomized double-blinded two-year intervention study with topical application of latanoprost or placebo eye drops in patients with diabetic retinopathy.
Detailed description
The primary objective is to study if a sustained contraction of pathologically dilated retinal arterioles can be obtained. Retinal arteriolar diameter and the diameter response to increased blood pressure is studied using the Dynamic Vessel Analyzer (Imedos, Germany. The secondary objective is to study whether the intervention can halt the development of diabetic retinopathy, which is assessed by optical coherence tomography (OCT) scanning and fundus photography.
Interventions
DRUGLatanoprost
Topical application
Sponsors
Aarhus University Hospital
University of Aarhus
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 36 Years
Healthy volunteers
No
Inclusion criteria
* Age 20-36 years old * Diabetes mellitus with retinopathy
Exclusion criteria
* Pregnancy * Previous ocular disease other than diabetic retinopathy * General disease with possible influence on the eye
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The diameter of retinal arterioles | 24 months | The diameter of retinal arterioles will be assessed using the Dynamic Vessel Analyzer |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The severity of diabetic retinopathy | 24 months | Severity of diabetic retinopathy will be measured by optical coherence tomography (OCT) scanning and fundus photography |
Countries
Denmark
Outcome results
None listed