Perioperative Analgesia After Knee Arthroplasty

Perioperative Analgetic Therapy After Knee Arthroplasty

Status

UNKNOWN

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01225484

Enrollment

123

Registered

2010-10-21

Start date

2010-10-31

Completion date

2015-10-31

Last updated

2015-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Arthroplasty

Keywords

Knee arthroplasty, perioperative analgesia

Brief summary

The purpose of this study is to compare two accepted methods of pain control in knee arthroplasty surgery.The first method combines the periarticular injection of ropivacaine with continuous blockade of the femoral nerve.The second method uses periarticular infiltration of ropivacaine in combination with an bolus of ropivacaine into an intraarticular catheter placed intraoperatively followed by a continuous intraarticular infusion of ropivacaine. All patient will also receive a sustained-release oral opioid and oral rescue opioids determined by pain severity using the Visual Analog Scale (VAS)

Interventions

PROCEDUREContinuous femoral nerve block + periarticular infiltration

Initial bolus of ropivacaine 5mg/ml 30mls into the femoral-nerve-catheter preoperatively. Periarticular infiltration of ropivacaine 2mg/ml 150 mls intraoperatively. Continuous perineural infusion of ropivacaine 2mg/ml at a rate of 6 mls/hr postoperatively. Rate can be adjusted to achieve optimal pain control and avoid motor blockade.

PROCEDUREIntraarticular and periarticular ropivacaine

Periarticular infiltration of 150 mls ropivacaine 2mg/ml intraoperatively, intraarticular injection of 40 mls ropivacaine 2 mg/ml at skin closure followed by infusion of ropivacaine 2 mg/ml at a rate of 4 mls/hr delivered by an intraarticular catheter until the morning of postoperative day 3.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Elective primary knee arthroplasty * ASA I,II,&III patients * Spinal Anaesthesia

Exclusion criteria

* Patients refusing consent * Contraindications to regional anaesthesia * Preexisting neurological disease * Alcohol or drug abuse * Inability to use the outcome assessment tools * Wheel chair or walker dependent * Pregnancy

Design outcomes

Primary

Measure	Time frame
Static and dynamic pain scores (VAS)	72 h

Secondary

Measure	Time frame
Maximum knee flexion (active/passive)>= 90°	72 h

Countries

Austria

Contacts

Primary ContactKarl Trauner, M.D.

karl.trauner@lkh-feldbach.at+43 3152 899 3701

Backup ContactAngelika Rohrleitner, M.D.

angelika.rohrleitner@lkh-feldbach.at+43 3152 899 3701

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026