Asthmatic Patients
Conditions
Brief summary
The main objectives of the study are: 1\. To unravel the importance of molecular phenotyping in predicting the response to classical anti-asthma treatment (leukotriene antagonists) The investigators have developed a non-invasive technique based on mRNA analysis of induced sputum that enables us to study airway inflammation in detail. This technique forms the basis for our current project based on the following hypotheses: 1. Different molecular asthma phenotypes exist: a Th2 phenotype and a non Th2 phenotype as reported by Woodruff and colleagues (Woodruff PG et al). Sputum mRNA cytokine levels can be used to diagnose Th2 asthma and discriminate this from non-Th2 asthma. 2. Based on our previous research and preliminary data that non-Th2 asthma can be further divided in Th17 asthma and Th1+Th2 asthma; besides these, a fourth group without Th2, Th17 or Th1 characteristics also exist. 3. These subgroups have different responses to anti-leukotrienes.
Interventions
DRUGMontelukast
Montelukast, 10 mg
DRUGlong acting beta2 mimetic
ICS+long acting beta2 agonist: twice daily
Sponsors
Universitaire Ziekenhuizen KU Leuven
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* uncontrolled persistent asthmatics on daily inhaled corticosteroids (GINA)
Exclusion criteria
* viral/fungal/bacterial infection +fever (\<1 month) * asthma exacerbation (\<3 months) * other respiratory disease (CF, ciliary dyskinesia,bronchiectasis) * cardiac patients using beta-blockers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sputum cytokine mRNA | 8 weeks |
Secondary
| Measure | Time frame |
|---|---|
| responsiveness to the medication | 8 weeks |
Countries
Belgium
Outcome results
None listed