Abdominal Aortic Aneurysm, Carotid Stenosis, Peripheral Arterial Disease
Conditions
Keywords
lower limbs, Arterial Diseases
Brief summary
The purpose of this study is to determine the prevalence and risk factors, at the time of the diagnosis of PAD, for asymptomatic carotid stenosis and abdominal aortic aneurysm.
Detailed description
The EVART study is a prospective epidemiological multicenter cohort study, including patients with newly diagnosed PAD (\< 1 year). Initial data on medical history, caracterisation of the PAD (risk factors, main sites and severity of the atherosclerotic lesions),clinical evaluation of undetected previous CV events, standardized US duplex examination of the abdominal aorta and carotid arteries and treatment (type and duration) are collected by the physician into an electronic medical record. A phone follow up at 3 months, 1, 2 and 3 years is realised by the Centre for Clinical Research of Grenoble. Data on mortality, revascularization, treatments prescribed (type and duration), cancer onset, cardiovascular events, carotid stenosis, abdominal aortic aneurysm are collected. All these serious adverse events are documented and reviewed by an independent critical events committee.
Interventions
OTHERpatients with newly diagnosed PAD (<1year)
patients with newly diagnosed PAD (\<1year) symptomatic or asymptomatic, without any history of previous coronary nor cerebrovascular event, and with no previous investigation of the aorta and cervical arteries were eligible
Sponsors
Institut de l'Atherothrombose
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patient with newly diagnosed PAD \< 1 year * symptomatic or asymptomatic : ABI\<0.9 at rest, claudicants with ABI\<0.85 after treadmill test, or symptomatic patients (Edimburgh questionnaire or trophic changes) with ABI\>1.30
Exclusion criteria
* history of previous coronory or cerebrovascular event * previous investigation of the aorta and cervical arteries * prisoners * subjets with no affiliation to the social security system or equivalent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| prevalence and risk factors, at the time of the diagnosis PAD, for asymptomatic carotid stenosis and abdominal aortic aneurysm | evaluation during inclusion visit |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| frequency of prescription of cardiac consultation,coronarography, stress ECG, stress echo, thallium scan and renal and digestive doppler ultrasound. Frequency of coronary and renal revascularization | evaluation during inclusion visit | — |
| frequency of drug prescription (beta blocker, statin,antiplatelet,ICE, other hypolipidaemic...) Non-drug prescription : dietetic, tabagism, rehabilitation for walking and structured therapeutic education, dietary management | evaluation during inclusion visit | — |
| clinical forms of aortic aneurysm and carotid stenosis, clinical stage of PAD, ABI level, proximal predominance, age, gender, cardiovascular risk factors will be tested like potential aneurysm or carotid stenosis risk factor | evaluation during inclusion visit | — |
| incidence of thromboembolic disease (symptomatic DVT and/or PE) proved by additional examinations | 3 Months, 1, 2 and 3 years | — |
| useful of the screening | 3 years | decision analysis |
| incidence and cardiovascular risk factor | 3 months, 1, 2 and 3 years | — |
Countries
Belgium, France
Outcome results
None listed