Adaptation of Lipid and Energy Metabolism During a Lipid Overnutrition in Constitutional Thinness

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01224561

Acronym

Surnutrition

Enrollment

Registered

2010-10-20

Start date

2008-03-31

Completion date

2011-01-31

Last updated

2011-05-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Constitutional Thinness, Lipid Overnutrition

Keywords

Thinness, Leanness, healthy volunteers, Lipid metabolism disorder

Brief summary

For a given food intake, fat and energy metabolism in adipose tissue and muscle adapt to nutrient intakes. This adaptation to nutrition may be impaired in susceptible individuals or in obese patients by promoting weight gain, either in constitutional thinness (MC) by blocking it. The MC is a little known entity. These patients wish to grow for her and others. Can they? We have demonstrated abnormalities of hormones regulating appetite (ghrelin, PYY, GLP1 and leptin) that may participate in thinness. Furthermore, this thinness is associated with osteoporosis in 25% of true MC who is 25 years old.

Detailed description

This project aims to overfed MCs and follow the control parameters of energy metabolism. We will look for abnormalities in the adaptation to overnutrition in subjects with genetic background of thinness, which could explain the resistance to weight gain. The answer could possibly help to understand obesity.

Interventions

BEHAVIORALLipid overnutrition

During 4 months, the daily caloric intake will be increased by about 70 g fat as butter 20 grams, 100 grams of cheese (Emmental) and 40 grams of almonds. This overnutrition corresponds to an excess of 760 kcal / day or 21,280 calories for the period and then taken to a theoretical 2.4 kg of fat (1 kg fat = 9000 kcal).

Study design

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* consent form the study signed * consent form for genetic study signed * normal laboratory values for liver enzymes, glucose, lipid

Exclusion criteria

(common to the two groups): * pregnant * vegetarian * heavy smoking * heavy alcohol * depressive * taking hypolipidemic or antihypertensive drugs * dyslipidemia

Design outcomes

Primary

Measure	Time frame	Description
gene expression	After one month of lipid overnutrition	Level of genes (which regulate the lipid and energy metabolism) expression in fat and muscle tissues

Secondary

Measure	Time frame	Description
Anthropometric parameter	After one month of lipid overnutrition	Lean mass
Autonomic nervous system activity	After one month of lipid overnutrition	Heart rate variability analyses using ECG Holter monitoring
gastrointestinal hormone level	After one month of lipid overnutrition	Serum level of GLP1

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026