Selenium Status Measured in Blood After a Higher Intake of Fish and Shellfish - a Randomized Dietary Intervention Study

Status

Completed

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01224249

Enrollment

102

Registered

2010-10-20

Start date

2010-08-31

Completion date

2011-03-31

Last updated

2011-09-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Selenium Status, Selenium Uptake From Fish and Shellfish

Keywords

Selenium, Selenoprotein P, Fish, Shellfish, Bioavailability

Brief summary

The primary aim of this study is to investigate, whether higher intake of selenium rich food items such as fish and shellfish, is associated with higher selenium blood levels. The secondary aim is to investigate the uptake of selenium from fish and shellfish and the incorporation of selenium from those foods into proteins in the human body. Furthermore, the impact of the natural variation in the genes that are responsible for the accumulation of selenium in the proteins will be investigated.

Detailed description

Selenium is an essential trace element that is incorporated into proteins in the human body and it hereby plays a major role in several important cellular processes. Previous studies have indicated that the selenium status of the Danish population is below the levels required to optimize the suggested protective effects of selenium towards major diseases including cancer. In Denmark, important natural sources of selenium are fish and shellfish.

Interventions

DIETARY_SUPPLEMENTFish and shellfish

Intake of 1000 grams of fish and shellfish per week for six months.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

50 Years to 74 Years

Healthy volunteers

Yes

Inclusion criteria

* men and women * 50-74 years * BMI 18.5-28 kg/m2 * non-smokers

Exclusion criteria

* strenuous exercise \> 10 h/week * excessive intake of alcohol * frequent intake of fish and shellfish \> 200-300 g/week * intake of dietary supplements 3 months before or during the study * frequent use of medication except antihypertensive medicine, cholesterol lowering medicine and hormone replacement medicine * simultaneous participation in other research projects * cancer diagnosis within the past 5 years * severe chronic diseases

Design outcomes

Primary

Measure	Time frame
Selenium concentration in whole blood	Measured at baseline

Secondary

Measure	Time frame
Selenoprotein P in plasma	Measured at baseline
Genetic polymorphisms in the selenoprotein P gene	Measured at baseline
Heavy metals in whole blood (lead, cadmium, and mercury)	Measured at baseline
Blood pressure	Measured at baseline
Anthropometry (weight, height, waist, and hip circumference)	Measured at baseline

Countries

Denmark

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026