Asthma
Conditions
Keywords
asthma
Brief summary
Myeloid-derived suppressor cells (MDSC) have been studied for their ability to suppress T cell responses in vivo and in vitro. As a result, MDSC can regulate cellular responses to chronic inflammatory conditions such as cancer, leading to the induction of tolerance and, ultimately, tumor escape from immune surveillance.
Interventions
None listed
Sponsors
University of South Florida
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
Inclusion 1. Ages eligible for study: 18 to 60 years 2. Genders eligible for study: male and female 3. Signed and dated written informed consent is obtained prior to study blood draw. 4. Subjects being actively treated for chronic moderate to severe asthma based on National Heart Lung and Blood Institute guidelines (figure 1). Subjects must carry the diagnosis of asthma (made by a physician) for a minimum of six months. 5. Subjects within the first seven days of an acute asthma exacerbation, as determined by the referring physician. 6. Able to give informed consent.
Exclusion criteria
1. Use of systemic corticosteroids within the previous two weeks. 2. Pregnant and/or lactating females. 3. Current tobacco use. 4. Severe psychiatric illness. 5. Current illicit substance abuse or dependence and/or abuse of alcohol. 6. Current use of anti-microbial medications. 7. Primary or secondary immunodeficiency. 8. Any clinically significant uncontrolled medical condition that would put the patient's safety at risk.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To identify and characterize specific cell types (human dendritic cells, myeloid-derived suppressor cells and T lymphocytes) that are present in acute and chronic asthma. | one year from start of study |
Countries
United States
Outcome results
None listed