Atherosclerosis, Endothelial Dysfunction
Conditions
Brief summary
The aim of this study was to measure the effect of moderate and intensive lipid-lowering treatment with rosuvastatin on the endothelial function.
Interventions
DRUGRosuvastatin 5mg/day
Rosuvastatin 5mg/day
DRUGRosuvastatin 40mg/day
Rosuvastatin 40mg/day
Sponsors
Odense University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 81 Years
Healthy volunteers
No
Inclusion criteria
1. STEMI 2. no prior treatment with statins
Exclusion criteria
1. age below 18 or above 81 years 2. unconscious patients 3. serum creatinine \> 176μmol/L 4. total-cholesterol \> 7.0 mmol/l 5. hypothyreoidism ((TSH \> 1.5 x ULN (upper limit of normal)) 6. current liver disease (ALAT \> 2 x ULN) 7. unexplained creatine kinase \> 3 x ULN 8. alcohol or drug abuse within the last five years 9. prior myopathy or serious hypersensitivity reaction caused by statins 10. women with childbearing potential who were not using chemical or mechanical contraception 11. pregnant or breastfeeding women 12. history of malignancy unless a disease-free period of more than five years was present 13. patients with abnormal lung function test (LFT) 14. participation in another investigational drug study less than four weeks before enrolment in the present study 15. treatment with cyclosporine or fibrates.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change from baseline in endothelium-dependent flow mediated vasodilatation of the brachial artery. | One year |
Secondary
| Measure | Time frame |
|---|---|
| The change from baseline in endothelium independent flow mediated vasodilatation of the brachial artery | One Year |
Countries
Denmark
Outcome results
None listed