Study of Gene Associations and Infertility

Genes and Gene Polymorphisms Associated With Infertility: Utilization of DNA Characteristics to Better Understand Reproductive Competence

Status

Enrolling by invitation

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01223092

Enrollment

5000

Registered

2010-10-18

Start date

2006-02-28

Completion date

2026-12-31

Last updated

2025-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Keywords

IVF, infertility, DNA

Brief summary

The purpose of this this study is to use DNA screening strategies to identify genes and localize genomic regions that are differentially expressed in patients with infertility to further understand the genetic basis for reproductive competence.

Detailed description

Experimental strategies seek to discover small variants in DNA sequences, which are associated with certain infertility parameters. The alleles being analyzed in in vitro fertilization (IVF) population are sought to be associated with functional differences in the expression of the gene product that are then mechanistically linked to infertility.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* all patients undergoing fertility care

Exclusion criteria

* none

Design outcomes

Primary

Measure	Time frame
Number of retrieved oocytes	1 month

Secondary

Measure	Time frame	Description
Fertilization rate	1 month	Number of oocytes that are fertilized
Number of available embryos	1 month	Number of embryos that are available for transfer on day 3 or day 5
Pregnancy rates	1 year	Clinical pregnancy rates (detection of pregnancy hormone bHCG in blood) and delivery rates.

Countries

United States

Outcome results