Impact of Adnexal Involvement of the Severity and Prognosis of Chronic Graft-versus-Host Disease

The Impact of Adnexal Involvement of the Severity and Prognosis of Chronic Graft-versus-Host Disease

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01221766

Enrollment

Registered

2010-10-15

Start date

2010-09-30

Completion date

2014-10-31

Last updated

2015-03-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cGVHD, Chronic Graft vs Host Disease, Graft vs Host Disease

Keywords

adnexal, hair and nail, chronic graft vs host disease, children

Brief summary

This research study will help us learn more about how chronic graft-versus-host disease affects the skin, hair and nails. We are interested in knowing if hair and nail problems predict worse disease. This information may help us treat patients like you in the future.

Detailed description

* At the initial visit, participants will have a complete examination of their skin, hair and nails. We will also test muscle strength and movement by moving the participant's arms, legs and neck. Photographs will be taken of the skin, hair and nails of they are abnormal. Blood tests will be done to check the liver and blood cell count. The participant and their legal guardian will answer questions about how the participant feels and about their health. * Participants will then be scheduled for follow up visits at 3 months, 6 months, and 12 months. At each subsequent visit the following will be done: A complete examination of the skin, hair and nails; a test of muscle strength; photographs will be repeated; blood tests to check liver and blood cell counts; and questions about how the participant feels and about their health.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Received hematopoietic stem cell transplant * Meet the diagnostic criteria for cutaneous cGVHD

Exclusion criteria

* Previous HSCT (other then the current HSCT)

Design outcomes

Primary

Measure	Time frame	Description
Adnexal involvement	1 year	To determine if adnexal involvement predicts worse severity and/or prognosis in chronic GVHD. This will be measured by administration of systemic therapy other than steroids.

Countries

United States

Outcome results