Liver Regeneration After Liver Resection

An Observational Study of Liver Regeneration After Right Hepatectomy: Understanding the Molecular Primers of Liver Regeneration

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01220986

Enrollment

Registered

2010-10-14

Start date

2010-08-31

Completion date

2012-08-31

Last updated

2010-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatectomy, Liver Diseases

Keywords

Liver regeneration, Innate immune response

Brief summary

The aim of this study is to characterize Kupffer cell activity and activation of the innate immune response in the early phase of liver regeneration after right hepatectomy. The investigators hypothesise that liver regeneration after right hepatectomy in humans is associated with Kupffer cell activation and initiation of the innate immune response and that impaired liver regeneration, liver failure and sepsis following liver resection are associated with Kupffer cell dysfunction and an impaired innate immune response. The objectives for this study are to characterise Kupffer cell activity and the innate immune response in human liver before and after right hepatectomy.

Interventions

PROCEDURELiver biopsy

0, 30, 60, 90 min post inflow-division

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Patients requiring right hepatectomy for colorectal liver metastases

Exclusion criteria

* Age \>75, neoadjuvant chemotherapy, recurrent disease

Countries

United Kingdom

Contacts

Primary ContactJohn S Hammond, BM.BS PhD

john.hammond@nottingham.ac.uk01159249924

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026