In Vitro Fertilization
Conditions
Keywords
methylprednisolone, IVF, progesterone, corticosteroid, late follicular phase, pregnancy rates
Brief summary
Hypothesis to be tested is whether follicular addition of Methylprednisolone can efficiently control late follicular progesterone rise during IVF treatment
Detailed description
The aim is to investigate any potential advantages of adding cortisone supplementation from the follicular phase onwards with regard to premature luteinization, oocyte quality, embryo quality and pregnancy outcome.
Interventions
OTHERIn vitro fertilization treatment for infertility
IVF treatment
Sponsors
BioGenesis
HRG
Universitair Ziekenhuis Brussel
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Eligibility
Sex/Gender
FEMALE
Age
21 Years to 36 Years
Healthy volunteers
No
Inclusion criteria
* less than 36, more than 10 antral follicles, FSH\<12
Exclusion criteria
* endometriosis stage III&IV,
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Progesterone rise above 1.5ng.ml on the day of HCG | up to 14 days of follicular ovarian stimulation | Incidence or high progesterone on the day of HCG triggering |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Clinical pregnancy rate | Follow pregnancy until delivery | Success rate in IVF cycles |
Countries
Greece
Contacts
Primary ContactEvangelos Papanikolaou, MD
Outcome results
None listed