Pancreatic Cancer
Conditions
Keywords
Pancreatic intraepithelial neoplasia (PanIN), Pancreatic Cancer, Recurrence of pancreatic cancer, Field Effect, Genetic mutations in pancreatic cancer
Brief summary
The research purpose of this project is to create a registry, and blood and tissue bank for individuals at high-risk for pancreatic cancer. We plan to conduct histopathological and molecular analysis of resected pancreatic tissue prospectively collected from a cohort of pancreatic cancer patients.
Detailed description
Pancreatic cancer is the fifth leading cause of cancer-related death in the United States. In order to improve outcomes of this disease, significant research efforts have focused on understanding the changes that occur in the pancreas prior to tumor occurrence. The types of changes most often associated with tumor have been named pancreatic intraepithelial neoplasia (PanIN). It is not yet clear how to identify the PanIN lesions most likely to develop into cancer and the length of time required for this progression. In order to evaluate these questions, we are interested in examining the microscopic and genetic characteristics of PanIN lesions in two high-risk patients: 1) patients who underwent surgery for pancreatic cancer and developed tumor recurrence after surgery and 2) patients with a strong family history of pancreatic cancer or with a genetic syndrome that puts them at risk for pancreas cancer. The surgical specimens from these patients will be evaluated by a pathologist for evidence of widespread PanIN lesions. In addition, PanIN lesions will be tested for abnormalities in several major genes that are known to be important in pancreatic cancer.
Interventions
None listed
Sponsors
Cold Spring Harbor Laboratory
Columbia University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Tissue-confirmed diagnosis of pancreatic adenocarcinoma. * Underwent surgical resection for adenocarcinoma at Columbia-Presbyterian Medical Center with pathologically negative surgical margins. * Enrolled in our Pancreatic Cancer Registry and Tissue Bank protocol (AAAA-6154). * Have at least 2 relatives (of whom one must be first-degree relative) with pancreatic cancer, or have been diagnosed with a a genetic syndrome which is associated with pancreatic cancer (among the included syndromes include BRCA1/2, FAMMM, Peutz-Jeghers, HNPCC, Hereditary Pancreatitis) -OR- Have radiological or pathological (fine needle aspirate or surgical biopsy) evidence of local tumor recurrence following surgery.
Exclusion criteria
* Metastatic disease discovered at presentation or on recurrence (exception is the familial PDC patients) * Positive surgical margins. * Lack of clinical followup at one year following surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of subjects with histological features of PanIN lesions assessed | 1 year | Distinctive histological features of PanIN within surgical specimens of our two study groups will be assessed by pathologists. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of clonality multifocal PanIN lesions | 1 year | Using microarray-based comparative genomic hybridization (aCGH) to evaluate the samples. |
| Evaluation of Recurrence Mechanism in PDC | 1 year | aCGH will also be utilized to evaluate recurrence mechanism in a set of cases in which both original tumor and recurrence tumor was resected, allowing for clonal origins to be evaluated. |
Countries
United States
Outcome results
None listed