Cardiovascular Disease
Conditions
Keywords
Body composition, Endothelial function, Lipoprotein profile, Inflammatory markers, Aerobic capacity, Thrombotic markers, Arterial stiffness, Cardiac function, Traditional and emerging cardiovascular disease risk factors
Brief summary
The purpose of this study was to examine the effect of 6 months moderate intensity exercise training completed three times per week upon traditional and emerging cardiovascular disease risk factors in postmenopausal women both with and without type 2 diabetes. These risk factors include blood markers associated with increased risk such as cholesterol, insulin, glucose and markers of inflammation plus measures of body fat, heart and lung fitness, vascular stiffness and vascular function. The study hypothesised that moderate intensity exercise training would intervene in the exaggerated risk seen in women following the menopause, especially in those with type 2 diabetes.
Interventions
BEHAVIORALExercise training
6 months of moderate intensity exercise training 3 times per week
Sponsors
University of Leeds
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
45 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy and stable type II diabetic postmenopausal women (cessation of menstrual periods for 12 months and confirmed with LH/FSH samples) aged 45 - 65 years old for the cross sectional analysis and exercise training study.
Exclusion criteria
* Identified abnormalities during baseline testing. * Vigorously active women. * Women who are pregnant. * Women with serious systemic or psychological disorders (e.g. COPD, asthma, clinical depression). * Women with known coronary artery disease. * Women with significant cardiovascular pathologies and associated medication. * Women with type 1 or insulin treated diabetes. * Women with diabetes with complications. * Women with unstable diabetes or hypertension. * Women with any cancer. * Women with musculoskeletal impairments or contraindications to exercise.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Maximal oxygen uptake | 6 months |
Secondary
| Measure | Time frame |
|---|---|
| Flow mediated dilation | 6 months |
| Cardiac power output | 6 months |
| lipoprotein profile | 6 months |
| Inflammatory markers | 6 months |
| Body composition | 6 months |
| Arterial stiffness | 6 months |
Countries
United Kingdom
Contacts
Primary ContactKaren M Birch, BSc, PhD
Outcome results
None listed