Exercise as a Strategy to Treat Cognitive Dysfunction in Persons With Multiple Sclerosis

Status

Completed

Phases

Phase 1Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01219647

Acronym

CogEx

Enrollment

Registered

2010-10-13

Start date

2010-07-31

Completion date

2014-08-31

Last updated

2014-12-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis

Keywords

Multiple Sclerosis, Exercise, Cognition

Brief summary

Many persons with Multiple Sclerosis ( MS) have problems with memory and thinking.Exercise has been shown to improve memory and thinking in persons with diseases such as Alzheimer's. This study will investigate whether a program of aerobic exercise can improve memory and thinking in persons with MS

Detailed description

Persons with Multiple Sclerosis(MS)will be screened for eligibility and randomized to a protocol with two intervention arms. One group will have aerobic training on a recumbent cross trainer three times a week for 20-30 minutes/session. The other group will participate in stretching exercises at the same frequency and intensity.Total training time will be six months.Outcome measures will include tests of memory and thinking, and fitness measures.

Interventions

BEHAVIORALexercise

subjects will participate in one of two forms of exercise

BEHAVIORALstretching

subjects will particiopate in supervised stretching as described in arm description.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

* Clinical Diagnosis of MS Complaints of cognitive problems Able to ride a recumbent cross trainer

Exclusion criteria

* Cardiopulmonary or structural disease that would limit ability to participate in exercise training On treatment with chemotherapy or natalizumab Screening score of \>50 on PASAT

Design outcomes

Primary

Measure	Time frame	Description
Paced Auditory Serial Addition Test (PASAT)	36 weeks	test of attention and information processing

Secondary

Measure	Time frame	Description
Symbol Digit Modalities Test (SDMT)	36 weeks	test of attention and information processing
VO2 max	36 weeks	measure of fitness via oxygen consumption and use
Long latency cognitive event related potentials ( LLCERP)	36 weeks	electrophysiologic tests of information processing

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026