Impaired Glucose Tolerance
Conditions
Keywords
Exercise, elderly, cognition, prevention, cognitive decline, Lifestyle
Brief summary
The researchers will investigate whether exercise could provide positive effects on general brain functions in elderly people with impaired glucose tolerance.
Detailed description
The age-related degradation of cognitive functions even to the point of neurodegenerative disorders such as Alzheimer's disease are a growing public-health concern with devastating effects. Referring to animal data, empirical studies, and pilot human trials, exercise should improve cognitive functions such as learning and memory. To test this hypothesis, the researchers study general brain functions in elderly subjects (50-80 years old) with impaired glucose tolerance during a short term exercise program.
Interventions
BEHAVIORALExercise
6 months of aerobic exercise
Sponsors
German Federal Ministry of Education and Research
Charite University, Berlin, Germany
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* subjects with impaired glucose tolerance * 50-65 years old * moderate to heavy weight (BMI 25-35) * must be able to do exercise intervention
Exclusion criteria
* diabetes * younger than 50 years * BMI \< 25 * psychiatric medication * severe disease * MMSE \< 26 * severe cardiovascular disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Auditory Verbal Learning Task | Prior to intervention and after 6 months of intervention |
Secondary
| Measure | Time frame |
|---|---|
| Functional/Structural brain changes | Prior to intervention and after 6 months of intervention |
| Plasma biomarkers | Prior to intervention and after 6 months of intervention |
Countries
Germany
Outcome results
None listed