Extremely Low Birth Weight Infants, Hypernatremia
Conditions
Keywords
Extremely Low Birth Weight Infants, Hypernatremia, Enteral Sterile Water Feeds
Brief summary
The improved survival rate of extremely low birth weight(ELBW)infants has resulted in new fluid and electrolyte problems that have not been encountered previously,in particular electrolyte imbalance. ELBW infants are especially vulnerable to hypernatremia(serum sodium value \>150 mEq/L). Hypernatremia may be due to rapid dehydration or excessive administration of intravenous fluids(IV)that contain sodium. The current treatment modality for hypernatremia is to increase IV fluids above daily requirements.Enteral sterile water feeds(ESWF)are theorized as an endogenous source of fluids that may decrease elevated electrolytes such as sodium and potassium in premature infants. By giving ESWF to decrease elevated electrolytes, there would be less need for large volumes of IVF that contribute to the co-morbidities of prematurity: bronchopulmonary dysplasia (BPD),intraventricular hemorrhage(IVH)and patent ductus arteriosus(PDA). The purpose of this proposed study is to determine whether enteral sterile water feedings is effective in decreasing the incidence, duration and severity of hypernatremia in ELBW infants.
Interventions
OTHERSterile water feedings
Control group- no intervention Prophylactic group will receive sterile water feeds starting at 24 hours of life if/or when their serum sodium value is ≥ 145 mEq/L. The volume of sterile water is 10mls/Kg/day based on birth weight, given via continuous infusion feed. The feeding will be stopped when the serum sodium value is ≤ 140 mEq/L. The hypernatremia group will receive sterile water feeds when their serum sodium value is ≥ 150 meq/L. The volume of sterile water is 10 mls/Kg/day based on birth weight,given via continuous infusion feed. The feeding will be stopped when the serum sodium value is ≤ 140 mEq/L.
Sponsors
Case Western Reserve University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
24 Hours to 28 Weeks
Healthy volunteers
No
Inclusion criteria
* Infants less than or equal to 1,100 grams birth weight * Less than or equal to 28 weeks gestational age
Exclusion criteria
* \* Congenital heart disease, other than a PDA * Major congenital anomalies * A surgical condition (gastroschisis,omphalocele) * Renal disease * Hypotension treated with pressor support * Reverse end diastolic flow on Doppler study prior to delivery * Emergency medication received in the delivery room,except fluid boluses * Apgar scores recorded at 10 minutes of life \< or up to 5 and/or pH less than 7.0 on the first blood gas upon admission to the NICU
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| serum sodium values | Every 12 hours for 7 days | electrolytes will be measured every 12 hours from admission through the first seven days of life |
Countries
United States
Outcome results
None listed