Obesity, Weight Control, Weight Loss
Conditions
Brief summary
This study is designed to determine whether obese, normal weight, and successful weight loss maintainers differ in their food choice decision-making and/or executive function, and whether participation in a behavioral weight loss program leads to neural and/or behavioral changes. The investigators will examine behavioral performance on several tasks involving decision-making and self-control in conjunction with brain imaging data acquired during a food-choice decision-making task. Participants enrolled in the behavioral weight loss program will also be assessed following the treatment.
Interventions
BEHAVIORALCHOICES - obese
Standard group behavioral weight loss treatment
Sponsors
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
California Institute of Technology
The Miriam Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
35 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* women, ages 35-55, who are either currently obese (BMI = 30-40 kg/m2), always normal weight (lifetime BMI \< 25, NW) or successful weight loss maintainers who have lost 10% of their body weight and maintained that loss for at least 1 year (lifetime maximum BMI = 30-40 kg/m2)
Exclusion criteria
* weight loss medications, binge eating, standard MRI contraindications (e.g., metal implants, claustrophobia, pregnancy), left-handedness, food allergies, neurological or psychiatric conditions, including but not limited to schizophrenia, bipolar disorder, epilepsy, stroke and traumatic brain injury with loss of consciousness, and, among obese participants, inability to participate at two time points and lack of interest in participating in a behavioral weight loss trial * serious current physical disease (e.g., heart disease and cancer) for which physician supervision of diet and exercise prescription is needed, physical problems that limit the ability to exercise, participation in a weight loss program in the last 2 months and intention to become pregnant in the next 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fMRI | pre- and post-treatment in obese group, single time point for SWLM and NW |
Secondary
| Measure | Time frame |
|---|---|
| Behavioral data | pre- and post-treatment of obese group, single time point for SWLM and NW |
Countries
United States
Contacts
Primary ContactKathryn E Demos, PhD
Outcome results
None listed