Bleeding, Blood Transfusion
Conditions
Keywords
bleeding, blood sparing procedure, desmopressin, aggregometry, thromboelastography
Brief summary
Many patients undergo cardiac surgery without proper suspension of antiaggregation drugs. This is blamed to increase dramatically bleeding and use of allogenic blood transfusions. The investigators test the hypothesis that routine use of aggregometry could show antiaggregated patient and lead to normalization of platelet function via administration of Desmopressin thus limiting bleeding and transfusions.
Interventions
DEVICEAggregometry+Thromboelastography
Patients undergo standard thromboelastography and subsequent aggregometry to test effectiveness of residual antiaggregation drugs. Patients found to have altered value undergo optimization with desmopressin.
DEVICEThromboelastography Alone
Patients undergo standard of care Thromboelastography to evaluate overall coagulation performance.
Sponsors
Cardiochirurgia E.H.
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* all patients undergoing surgical myocardial revascularization.
Exclusion criteria
* none.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Bleeding Volume | 12 hours after end of operation | Total amount of bleeding in the first 12 hours after cardiac surgery expressed as milliliters of blood in the chest drains reservoir. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Use of allogenic blood transfusions. | In hospital stay (usually 5 to 8 days after operation) | Number of allogenic blood units transfused per patients during the full hospital stay, usually 5 to 8 days after operation. |
Countries
Italy
Outcome results
None listed