Ascitis, Cirrhosis
Conditions
Brief summary
Evaluation of kidney function is critical in cirrhotic patients as there is a clear relationship between renal failure and prognosis. The investigators hypothesized that in this population new biomarkers of renal function could help in early detection of acute renal failure and in discrimination between renal and pre-renal causes. Finally the investigators hypothesized that such biomarkers could predict short-term outcome in this population.
Interventions
None listed
Sponsors
University Hospital, Geneva
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥ 18 years * Known or suspected cirrhosis * Suspected ascitis * Informed consent signed
Exclusion criteria
* Proven multifocal hepatocellular carcinoma * Acute gastric hemorrhage (active or \< 2 weeks) * Known end-stage renal disease or on dialysis before admission * Recipients of kidney or liver transplants * Transferred from another institution
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Early detection of acute kidney injury in hospitalized cirrhotic patients with ascitis using new renal biomarkers | 30 days | Acute kidney injury will be defined using RIFLE and AKIN criteria. |
Secondary
| Measure | Time frame |
|---|---|
| Prediction of adverse clinical outcomes (Renal replacement therapy, transfer to ICU, all cause mortality). | 30 days |
| Discrimination between different type of AKI. | 30 days |
| Prediction of AKI developement using renal artery resistive indexes. | 30 days |
Countries
Switzerland
Outcome results
None listed