Juvenile Systemic Lupus Erythematosus, Juvenile Dermatomyositis
Conditions
Keywords
rheumatology, creatine supplementation, quality of life, strength, juvenile systemic lupus erythematosus, juvenile dermatomyositis
Brief summary
Creatine supplementation may improve strength, muscle mass, bone mass and muscle function in healthy and elderly people. The investigators speculate that creatine supplementation could have therapeutic effects in pediatric rheumatic (i.e., juvenile systemic lupus erythematosus and juvenile dermatomyositis) patients who usually present muscle weakness, muscle wasting and bone mass loss.
Interventions
DIETARY_SUPPLEMENTcreatine
5g/d throughout 12 weeks
DIETARY_SUPPLEMENTplacebo (dextrose)
5g/d throughout 12 weeks
Sponsors
University of Sao Paulo
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
6 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* patients diagnosed with lupus systemic erythematosus and juvenile dermatomyositis * physically inactive * stable pharmacological treatment
Exclusion criteria
* macroalbuminuria * GFR \< 30 mL/min/1.73m2 * use of oral anticontraceptive agents * pregnancy * diabetes mellitus * hypothyroidism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| muscle strength | after six months |
Secondary
| Measure | Time frame |
|---|---|
| kidney function parameters | after six months |
| quality of life | after six months |
| muscle function | after six months |
Countries
Brazil
Contacts
Primary ContactBruno Gualano, PhD
Outcome results
None listed