Study of Resistance Strengthening Versus Ambulation Post-Liver Transplant

Comparison of Targeted Lower Extremity Strengthening and Usual Care Progressive Ambulation in Subjects Post Liver Transplant: A Randomized Controlled Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01216722

Enrollment

Registered

2010-10-07

Start date

2007-10-31

Completion date

2010-07-31

Last updated

2010-10-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Activities of Daily Living, Liver Transplantation, Resistance Training

Keywords

Muscle Wasting, Strengthening, Liver Disease, Transplant

Brief summary

Resistance strengthening exercise will increase strength and functional activity greater than ambulation in subjects post-liver transplantation.

Detailed description

Individuals post liver transplantation are significantly muscle wasted due to chronic liver disease. Current Usual care only involves progressive ambulation. Resistance exercise targeted at the lower extremities are anticipated to increase muscle strength in the muscles that extend the hip, extend the knee, and plantar flex the ankle more than seen with the usual care ambulation. The anticipated increases in strength should improve functional performance of activities such as standing from a chair, walking, and climbing stairs. The improvement in strength and functional performance should improve an individuals quality of life.

Interventions

OTHERResistance Strengthening Exercise Program

Home exercise Program. 3-4 days a week. 30 minutes a session. 12 weeks

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Undergone Liver Transplantation a minimum of 6 weeks and a maximum of 12 weeks prior to enrollment * Ambulatory without physical assistance, but permitted to use a cane or walker

Exclusion criteria

* Diagnosis of Hepatocellular Carcinoma * Significant Cardiopulmonary disease * Neurological / Neuromuscular Disorder including cerebral vascular accident (CVA), Parkinson's Disease, Alzheimer's Disease, Dementia unrelated to Hepatic Encephalopathy, dystonia, multiple sclerosis, and polio. * Blindness * Inability to comprehend the English or Spanish Language

Design outcomes

Primary

Measure	Time frame
Six Minute Walk Test	Baseline
Heel Rise Test	Baseline
30-Second Chair-Stand Test	Baseline
Bridge Test	Baseline

Secondary

Measure	Time frame
Short Form (SF-36) Questionnaire	Baseline
Chronic Liver Disease Questionnaire (CLDQ)	Baseline

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026