Chronic Obstructive Pulmonary Disease
Conditions
Keywords
COPD, Airway inflammation, Symptoms, Lung function, Correlation
Brief summary
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease with high prevalence worldwide and with relevant impact on patient-related quality of life, morbidity and mortality. There is evidence that airway inflammation correlates with the severity of the disease and that airway inflammation is further enhanced during exacerbation. However, it is unknown whether daily fluctuation of symptoms or changes in lung function is paralleled by changes in airway inflammation.
Detailed description
Patients will undergo a visit every 7 days during one month (5 visits in total). At each visit airway inflammation (exhaled NO, sputum inflammatory cell count) and lung function will be performed. At home patients will be asked to fill a daily diary for symptom assessment.
Interventions
OTHERCOPD treatment
Patients, will be asked to continue their previous medication (GOLD guidelines) during the study. No interventional change in COPD treatment will be performed during the study.
Sponsors
AstraZeneca
Università degli Studi di Ferrara
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Post-bronchodilator FEV1/FVC ratio \< 70% * Post-bronchodilator FEV1 \< 80% * Smokers or ex-smoker with pack/years \> 15
Exclusion criteria
* Atopy * Asthma * Concomitant lung diseases (e.g. lung cancer) * Acute infections of the respiratory tree in the previous 2 months including COPD exacerbation.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between changes in airway inflammation and symptom score | 1 month, | Correlation between changes in airway inflammation and symptom score will be evaluated |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between changes in airway inflammation and lung function | 1 month | Correlation between changes in airway inflammation and lung function will be evaluated |
| Correlations between airway inflammation and symptom scores | 1 month | Correlation between markers of airway inflammation and symptom score will be performed |
| Correlations between airway inflammation and lung function | 1 month | Correlation between markers of airway inflammation and lung function will be assessed |
Countries
Italy
Outcome results
None listed