Preterm Neonates
Conditions
Keywords
Neonatal, Nasal CPAP, Randomized controlled trial, Weaning
Brief summary
To compare the 2 methods of weaning of nasal CPAP in premature babies born at 32 weeks or less
Detailed description
Objective: To study the weight and the post menstrual age (PMA) at the time of nasal CPAP (NCPAP) wean utilizing the method of sudden wean as compared to gradual wean. . Methods: A prospective randomized trial was conducted comparing sudden weaning with gradual weaning from NCPAP in neonates with gestational age (GA) \<32 weeks. The patients were randomized to one of the two methods of weaning from NCPAP and their success was compared.
Interventions
PROCEDUREGradual weaning from Nasal CPAP in preterm neonates
Nasal CPAP for gradual wean group it was cycled off for 3 hours alternating with 3 hours on for first 48 hours, if successful the cycle was extended to 6 hours off and 3 hours on for the next 48 hours. If the baby tolerated this regime the prongs were removed and CPAP was kept off.
Sponsors
Maimonides Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
24 Weeks to 32 Weeks
Healthy volunteers
No
Inclusion criteria
All babies born with GA \<32 weeks admitted to the neonatal intensive care units at the Maimonides Infant and Children's Hospital, between 1st January 2008 and 31st March 2009 and required to be on NCPAP for longer than 48 hours.-
Exclusion criteria
Those with severe congenital anomalies and chromosomal defects including congenital heart disease and neurological malformations, chest wall or airway abnormalities and lung hypoplasia, were excluded from the cohort
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Weight when preterm neonates could come off nasal CPAP | During the initial NICU stay | Weight when preterm neonates could come off nasal CPAP |
| Post-menstrual age when preterm neonates could come off nasal CPAP | During the initial NICU stay | Post-menstrual age when preterm neonates could come off nasal CPAP |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Weights when the neonates could come off oxygen | During the initial NICU stay | Weights when the neonates could come off oxygen |
| length of stay in the hospital | During the initial NICU stay | length of stay in the hospital |
| Post-menstrual age when preterm neonates could come off oxygen | During the initial NICU stay | Post-menstrual age when preterm neonates could come off oxygen |
Countries
United States
Outcome results
None listed