Heart Failure, Type 2 Diabetes
Conditions
Brief summary
The investigators wish to investigate wether a more strict diabetic control improves cardiac function, muscle strength, exercise capacity and decreases symptoms. The investigators hypothesis is that improving the glycemic control in suboptimized diabetics with heart failure will improve cardiac performance, muscle strength, exercise capacity and decrease symptoms.
Interventions
OTHERall antidiabetic drugs will be appliable
We expect all participants to be set on insulin during the intervention, however all types of insulin and other antidiabetics can be used goal: Hba1c lower than 7,5%
Sponsors
The Danish Diabetes Association
University of Aarhus
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Ejection fraction =\<45% * Diabetes * Hba1c =\>7,5% * In anticongestive treatment * NYHA class 2-4
Exclusion criteria
* Severe angina (CCS 3-4) * Hemodynamic significant heart valve disease * Congenital heart disease * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Left ventricular function | 4 month | Left ventricular function will be evaluated using echocardiografi measuring: \- 2D Ejection fraction (using an ultrasound agent), global and regional tissue velocity, Strain / strain rate - all measures done during rest and dobutamin stress test. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| hormonal and metabolic profile | 4 month | bloodsamples |
| 6-minutes hall walk test | 4 month | using a hall walk protocol |
| Exercise capacity and peak oxygen consumption | 4 month | using a treadmill test and continues oxygen consumption measurement |
| Muscle strength and mass | 4 month | muscle strength: hand grip test |
Countries
Denmark
Outcome results
None listed