Mild Cognitive Impairment (MCI)
Conditions
Brief summary
The purpose of this study is to learn if activities that challenge the brain (mentally stimulating activities) can improve memory and other types of thinking in patients with Mild Cognitive Impairment. The study will compare the effects of different methods of mental stimulation.
Interventions
BEHAVIORALmentally stimulating activities
The study will compare the effects of different methods of mental stimulation. The intervention involves 6 classroom-style educational sessions and 10 mental stimulation studies involving computerized memory tasks.
Sponsors
National Institute on Aging (NIA)
Johns Hopkins University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* ≥ 50 years of age * meet criteria for amnestic-Mild Cognitive Impairment (MCI) * have capacity to give informed consent * have capacity to complete assessment measures
Exclusion criteria
* history of drug or alcohol dependence * severe psychiatric conditions associated with psychosis (e.g., schizophrenia) * recent stroke * clinical diagnosis of probable Alzheimer's Disease * history of seizure disorder, serious head trauma, or other medical, psychiatric, or neurological conditions associated with significant cognitive impairment (e.g., Parkinson's Disease, Korsakoff's, HIV) * current use of Alzheimer's Disease medications (e.g., cholinesterase inhibitors, memantine)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Self-Ordered Pointing Task | baseline |
| Trail-Making | baseline |
| Timed Instrumental Activities of Daily Living | baseline |
| Rey Auditory Verbal Learning Test | baseline |
| Self-ordered pointing task | immediately after the intervention |
Secondary
| Measure | Time frame |
|---|---|
| Neuropsychiatric Inventory | baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention |
| Recollection Task | baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention |
| N-Back | baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention |
| Clinical Dementia Rating Scale | baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention |
| Instrumental Activities of Daily Living | baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention |
| Functional Capacities for Activities of Daily Living | baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention |
| Multifactorial Memory Questionnaire | baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention |
| Rivermead Behavioral Memory Test | baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention |
| Digit Symbol Substitution Test | baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention |
| Digit Span | baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention |
| Verbal Fluency Test | baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention |
| Geriatric Depression Scale | baseline, immediately after the intervention, 3 months post intervention, and 9 months post-intervention |
Countries
United States
Outcome results
None listed