Gram-Positive Bacterial Infections
Conditions
Keywords
Gram positive infection and CRRT
Brief summary
Daptomycin kinetics in CRRT * Trial with medicinal product
Interventions
DRUGDaptomycin
Daptomycin kinetics in CRRT
Sponsors
University of Zurich
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* male or female of 18 years or older * females: negative pregnancy test * Hospitalisation in the medical ICU * High suspicion or evidence of Gram-positive infections requiring antibiotic therapy * Subjects receiving standard antibiotic treatment for Gram-positive infection * Evidence of renal failure * Clinical necessity for continuous renal replacement therapy * Written informed consent signed by the patient or a next of kin and an independent physician in case the patient is not able to sign.
Exclusion criteria
* Skeletal muscle disorders or CPK levels of \> 2 x ULN * History of hypersensitivity to the drug * Participation in another study * Subjects with a history of muscle disease * Patients with severe liver function impairment (Child * Life expectancy of less than 5 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pharmacokinetics | 2011 |
Countries
Switzerland
Contacts
Primary Contact01 Studienregister MasterAdmins
Outcome results
None listed