Healthy Individuals, Type 2 Diabetes
Conditions
Keywords
Branched Chained Amino Acids, Delayed Onset Muscle Soreness, Diabetes, Muscle Damage
Brief summary
The purpose of this study is to determine the effectiveness of the 3 Branched Chained Amino Acids (isoleucine, leucine, and valine) on treating Delayed Onset Muscle Soreness, a type of muscle pain which usually develops after exercising.
Detailed description
Delayed Onset Muscle Soreness is a common painful sensation experienced by individuals who have been recently inactive and begin with an unaccustomed exercise protocol. Branched Chained Amino Acids have been found as a useful supplement for promoting muscle recovery following exercise; however the effects of this supplement have not been investigated amongst individuals with diabetes.
Interventions
DIETARY_SUPPLEMENTBranched Chained Amino Acids
Two doses of the Branched Chained Amino Acid supplement will be taken. The first dose will be taken 35 minutes before the intended exercise, and the other dose will be taken right after completing the exercise. The amount of the Branched Chained Amino Acid supplement administered to the subjects in the experimental group will vary from one person to the other but a total dose of 1 gram of BCAA per kilogram of lean body mass will be used. This dose will be divided in half and administered at the two specified occasions. The ratio of isoleucine, leucine, and valine will be 1:2.5:1 respectively
OTHERCellulose Placebo mix
The control group will also take 2 doses, 1 before the exercise, and the other after completing the exercise. This dose will be divided in half and administered at the two specified occasions.
Sponsors
Loma Linda University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
20 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* The subjects with diabetes must have been diagnosed with diabetes at least one year before the onset of the study * At least 6 weeks of physical inactivity in the upper body * BMI less than 40
Exclusion criteria
* For the Diabetics, hemoglobin A1c levels over 13 * Pregnant * Have Cardiovascular diseases * Have Hepatic diseases * Are diagnosed with Rhabdomyolysis * Recent upper limb injuries * Upper limb neuropathy * Blood Pressure levels over 140/90, or lower than 90/60 * Are on High doses of alpha or beta agonist/antagonists, and take any types of NSAID's, Cox 2 inhibitors, Calcium channel blockers, Pre-Gabalin's, or Pain reducers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measuring Pain, using the short form McGill pain questionnaire | 5 days following the initial exercise |
Secondary
| Measure | Time frame |
|---|---|
| Measuring Muscle strength of the studied muscle | 5 days following the initial exercise |
Countries
United States
Outcome results
None listed