The Relationship Between Morphology and Virulent Genes of Candida Albicans and Clinical Aspects, Surveillance of Fungemia

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01211041

Enrollment

100

Registered

2010-09-29

Start date

2010-07-31

Completion date

2011-07-31

Last updated

2011-04-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Candidemia Prognostic Factor and Mycobiological Analysis.

Keywords

Candida albicans, fungemia , prognostic factor

Brief summary

Candida albicans is the most common and important clinical fungal pathogen. Our previous surveillance disclosed that fluconazole could induce different morphological changes in clinical strains. Our current study on C. albicans causing candiuria disclosed that renal insufficiency , diabetes mellitus, respiratory failure and uremia were risk factors of treatment failure. However, we also found results of E-test drug susceptible test could not predict outcome. Hence, retrospective analysis of 31 months period, cases that had C. albicans inducing candidemia were reviewed and 60 cases were enrolled for morphological study and potential virulent gene analysis. This study is designed to clarity the clinical meaning of morphological form and virulent genes on candidemia. To do this study is probably helpful for treatment of candidiasis.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* 2007 to 2010 medical records * Cases with candidemmia of Candida albicans with available clinical information in medical records for analysis. * Cases with candidemmia of Candida albicans which clinical isolates were preserved.

Exclusion criteria

* Cases were not hospitalized for treatment and data were not available for analysis.

Countries

Taiwan

Contacts

Primary ContactTsong-Yih Ou

93023@wanfang.gov.tw886-2-29307930

Outcome results