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Physiological Brain Atlas Development

Physiological Brain Atlas Development

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT01210534
Enrollment
456
Registered
2010-09-28
Start date
2010-08-31
Completion date
2021-10-18
Last updated
2023-02-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression, Dystonia, Obsessive Compulsive Disorder, Parkinson Disease, Tremors

Brief summary

Enrollment of candidates undergoing a deep brain stimulator (DBS) implant.

Detailed description

The study proposes the enrollment of candidates undergoing a deep brain stimulator (DBS) implant. Data will be collected before, during and after surgery and will be electronically entered into the Atlas database where it will be stored indefinitely. The purpose of the study is to create an Atlas to store physiological information utilizing non-rigid MRI normalization algorithms. In addition to collating and analyzing the physiological atlas in a statistical manner that allows the surgeon to predict optimal targeting locations for DBS implants based on multiple physiological variables, including pre-operative severity of disease, intraoperative neurophysiological observations, and post-operative response to DBS stimulation therapy.

Interventions

OTHERNo intervention

No intervention

Sponsors

Ohio State University
Lead SponsorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
7 Years to 90 Years
Healthy volunteers
No

Inclusion criteria

* Any patient between the age of 7-90 * Patients who have undergone deep brain stimulation (DBS) surgery as standard of care at The Ohio State University

Exclusion criteria

* None

Design outcomes

Primary

MeasureTime frameDescription
optimal DBS target locationintra-operative identificationTo create an atlas that will allow physiological information to be assigned to anatomical locations in MRI space, utilizing non-rigid MRI normalization algorithms.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026