Retinal Vascular Reactivity in Subjects With Newly Diagnosed Glaucoma Before and After Selective Laser Trabeculoplasty

Retinal Vascular Reactivity in Response to Isoxic Hypercapnia in Subjects With Newly Diagnosed Glaucoma

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01209975

Enrollment

Registered

2010-09-28

Start date

2008-11-30

Completion date

Unknown

Last updated

2010-09-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glaucoma

Keywords

blood flow, glaucoma, SLT

Brief summary

The purpose of this study is to assess retinal blood flow and vascular reactivity in patients with newly diagnosed primary open angle glaucoma pre- and post-primary Selective Laser Trabeculoplasty(SLT). Canon Laser Blood Flowmeter will be used for the assessment of retinal blood flow.

Detailed description

We previously found that vascular reactivity improved after short term treatment with dorzolamide drops. It is not clear whether this improvement was a direct effect of the medication or secondary effect of the decrease in IOP. We would like to see the change of vascular reactivity before and after SLT, which will decrease the intraocular pressure without pharmacologic effect.

Interventions

PROCEDURESelective Laser Trabeculoplasty

Patient will have selective laser trabeculoplasty as the first treatment for glaucoma. This treatment will be dictated clinically, since we do not assign the interventions.

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

40 Years to 75 Years

Healthy volunteers

Inclusion criteria

1. Age 40-75 years (Male or Female) 2. Best corrected visual acuity of at least 20/40 3. No previous treatment for glaucoma 4. Ametropia less than ±6.0 DS and ±2.5 DC) 5. Non-smoker 6. No cardiovascular/respiratory disorders

Exclusion criteria

1. Past history of diabetes and cerebrovascular accident 2. Vascular occlusive disease affecting the ocular circulation such as: diabetic retinopathy, retinal vein occlusion and retinal artery occlusion 3. Previous intraocular surgery 4. Ocular media opacities limiting the use of the imaging tests

Design outcomes

Primary

Measure	Time frame	Description
blood flow	before and two-week after SLT	The Canon Laser Blood Flowmetry will be used to assess the retinal blood flow.

Secondary

Measure	Time frame	Description
Intraocuclar pressure	before and two-week after SLT	Intraocular pressure (IOP) will be measured by Goldmann applanation tonometry.

Countries

Canada

Contacts

Primary ContactTien Wong

twong@uhnres.utoronto.ca416-603-5694

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026