Impact of Intensive Exercise Training on Coronary Collateral Circulation in Patients With Stable CAD

Impact of Intensive Exercise Training Compared to Inactive Controls on Coronary Collateral Circulation and Plaque Composition in Patients With Significant Stable Coronary Artery Disease

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01209637

Enrollment

Registered

2010-09-27

Start date

2010-03-31

Completion date

2012-12-31

Last updated

2016-10-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stable Coronary Artery Disease

Keywords

stable coronary artery disease, significant coronary stenosis

Brief summary

Exercise training in patients with coronary artery disease is able to correct several risk factors. Furthermore endothelial function can be improved. There are some hinds for improved collateral circulation after exercise training, nevertheless there is no study showing significant improvement/ increase in coronary collaterals. This might be due to technique of collateral measurement. Therefore we conduct a study were coronary blod flow before and after 4 weeks of exercise training were measured.

Interventions

BEHAVIORALexercise training

exercise training min. 4 times a day for at least 30 min

BEHAVIORALIntensive exercise training

Intensive exercise training for 4 times / day incl. interval training at 95% individual threshold

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* stable CAD * min.1 coronary artery stenosis \>50% * patient is symptomatic ( CCS 1-3)or has documented myocardial ischemia during stress test * angina threshold \>75 Watt * informed consent

Exclusion criteria

* Age \<18 oder \>75 * akut coronary syndrome within 2 weeks * LV-EF \< 40 % * significant valve diseases * reduced patient compliance * muscular disorder * bronchial asthma or COLD stadium III and IV

Design outcomes

Primary

Measure	Time frame
coronary collateral blod flow	4 weeks

Secondary

Measure	Time frame	Description
plaque composition within the coronary artery	4 weeks	plaque composition measured by virtual histology intravascular ultrasound
MACCE	4 week, 6 months, 12 months	major cardiovascular events (death, myocardial infarction, stroke, TIA, coronary revascularisation, hospitalisation)
atherosclerosis parameter within the laboratory	4 weeks, 3, 6, 12 months	e.g. wie hs-CRP, HDL, LDL, ges. Cholesterin, Triglyceride, Zytokine, Adipokine, Endocannaboide

Countries

Germany

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 25, 2026