Myocardial Reperfusion Injury
Conditions
Keywords
Myocardial infarction, Postconditioning, Microvascular obstruction, No reflow, MRI
Brief summary
After having shown that postconditioning allowed a significant 36% reduction of infarct size as assessed by blood levels of myocardial enzymes in acute myocardial patients, the investigators objective is to assess the effect of postconditioning in acute myocardial infarction (AMI) patients on microvascular obstruction lesions defined by cardiac MRI images.
Interventions
PROCEDUREpostconditioning
Direct postconditioning (brief repeated cycle of 4 occlusion and desocclusion of the initially occluded culprit coronary artery) after primary direct stenting.
Sponsors
Hospices Civils de Lyon
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients \> 18 years old, * Male or female, * Presenting first myocardial infarction, with the beginning of pains \< 12 hours, * Requiring a revascularisation by primary angioplasty or rescue (after failure of thrombolysis) on IVA or RCA (not CA). * Artery guilty with TIMI flow = 0
Exclusion criteria
* cardiac arrest before the angioplasty, * Cardiogenic shock * Occlusion of the artery circumflex responsible for the infarction * Magnetic resonance imaging: contre indication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Extent of the area of microvascular obstruction | 5 days | Extent of the area of microvascular obstruction defined on post-gadolinium CMR images realized 48-72 hours after admission in each group |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Size of the myocardial infarction | 5 days | Size of the myocardial infarction defined on post-gadolinium CMR images realized 48-72 hours after admission in each group. |
Countries
France
Outcome results
None listed